Phentermine side effects

Phentermine is a stimulant that can cause a range of side effects, from common issues like dry mouth and insomnia to rare but serious heart and lung problems . The side effects are typically most noticeable when you first start taking the medication .

Here is a breakdown of the potential side effects, organized by category and severity:

Common Side Effects

These side effects are relatively common and often improve as your body adjusts to the medication .

  • Body System Common Side Effects Management Tips
  • Central Nervous System Insomnia, restlessness, nervousness, dizziness, headache, tremors Take your dose early in the morning to prevent sleep problems. Avoid caffeine .
  • Cardiovascular Fast/irregular heartbeat (palpitations), increased blood pressure Monitor your heart rate and blood pressure if advised by your doctor. Avoid stimulants like caffeine .
  • Gastrointestinal Dry mouth, unpleasant taste, constipation, diarrhea For dry mouth, sip water often or chew sugar-free gum. For constipation, eat high-fiber foods and stay hydrated .
  • Other Changes in sexual desire or ability (impotence) Discuss any changes with your healthcare provider.

Serious Side Effects (Seek Medical Attention)

While less common, phentermine can cause serious side effects that require immediate medical attention . Call your doctor right away or seek emergency care if you experience:

  • Body System Serious Side Effects & Symptoms Notes
  • Cardiovascular (Heart & Lungs) Chest pain, shortness of breath (even with mild exertion), swelling in ankles/feet, fainting, decreased ability to exercise These can be signs of serious heart valve problems or a rare lung condition called pulmonary arterial hypertension .
  • Central Nervous System (Mental Health) Severe mood changes, agitation, aggression, hallucinations (seeing/hearing things), feeling unusually suspicious or confused Phentermine may cause psychosis or other severe psychiatric issues, especially with misuse .
  • Allergic Reaction Rash, hives, itching, swelling of the face/lips/tongue/throat, trouble breathing This is a medical emergency. Stop taking the medication and get help immediately.

Important Warnings and Precautions

  • Risk of Dependence: Phentermine is chemically related to amphetamines and is a Schedule IV controlled substance, meaning it has a potential for abuse and dependence . Do not increase your dose or take it for longer than prescribed .
  • Not for Long-Term Use: It is FDA-approved only for short-term use (a few weeks) as your body can build a tolerance to its effects .
  • Pregnancy and Breastfeeding: Do not take phentermine if you are pregnant, planning to become pregnant, or breastfeeding, as it may cause harm to the baby .
  • Driving and Operating Machinery: Phentermine can cause dizziness and affect your alertness. Avoid driving or hazardous activities until you know how the medicine affects you .
  • Drug Interactions: It is extremely important to tell your doctor about all medications you take. Taking phentermine with MAO inhibitors (within 14 days) or other weight loss drugs can cause dangerous interactions .

When to Contact Your Doctor

You should contact your doctor if you:
  • Experience any of the serious side effects listed above .
  • Have side effects that are bothersome or do not go away .
  • Feel the medication is not working as well after a few weeks (do not increase the dose on your own) .
  • Have not lost at least 4 pounds in 4 weeks .
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  • 6600 France Ave S, Suite 600, Edina, MN 55435